Fluensulfone

The Active Ingredient

Fluensulfone, the active ingredient in NIMITZ® Pro G, is the first new  chemical nematicide to be developed in more than 20 years. It is proving to be highly efficacious; providing revolutionary control of plant-parasitic nematodes with simple application features, a low level of human toxicity, and a favorable ecotox profile. Patented fluensulfone is created in ADAMA’s new manufacturing facility in Israel.

No other plant protection product in the world has the same mode of action or ability to deliver a higher level of efficacy from a single nematicide application program.

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Discovery

Fluensulfone, the active ingredient in NIMITZ Pro G was discovered in Japan and quickly showed significant promise for use as a replacement to outdated carbamate and organophosphate nematicides globally.

The development project was taken on by ADAMA (formerly Makhteshim-Agan) in 2006 and now after thousands of trials conducted in 23 countries over all continents, fluensulfone has consistently demonstrated equal or better nematode control when compared to the best commercial standards.

Structure

Chemical Name: 5-Chloro-2-(3,4,4-trifluoro-but-3-ene-1-sulfonyl) thiazole

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New Chemical Class: fluoroalkenyle (-thioether)

No other Plant Protection Products of the same chemistry.

Mode of Action Effects

 – Irreversible paralysis and impaired motility

  • Measureable effects starting as early as 6 hr. up to 24 hr. after application
  • Impaired motility and paralysis is irreversible after 24 hr. – true nematicide, not a transitory effect
  • Effects are seen at all developmental stages, but larvae at J2, J3 and J4 appear most susceptible.
  • Reduces thrashing, wriggling, or S-shaped movement – typical nematode motility

 – Effects on egg laying and hatching, growth and development

  • Some eggs are retained and do not hatch
  • Some eggs hatch within the adult giving a swollen or bloated appearance.
  • Most eggs that are laid never hatch
  • Eggs that do hatch do not progress beyond J1 stage.
  • Most likely nematicidal to the developing juvenile.
  • Possible interference with molting process.

 – Effect on feeding behavior

  • Adults exposed after 1 hour showed significant inhibition of esophageal pumping relative to a standard control.
  • Esophageal pumping was completely inhibited in juvenile stage J4 exposed to NIMITZ Pro G after only 1 hour.

NIMITZ Pro G starts working on contact

  • Reduced locomotion / paralysis
  • Cessation of feeding 1-hour after exposure
  • Reduction in ability to infest
  • Developmental effects on eggs:
    • Eggs do not develop
    • Reduced egg laying (Eggs may be retained in nematodes)
    • Reduced hatching
    • Juveniles that hatch don’t survive
    • Treated nematodes lay non-viable eggs